A simple and very sensitive spectrophotometric method was developed for determination of maprotiline hydrochloride. The method was based on the reaction of maprotiline base with π-acceptor 7,7,8,8-tetracyanquinodimethan in acetonitrile at 80oC for 20 min. to yield an intensely coloured purple product. Absorbances were measured at 567 nm. A linear relationship existed between absorbance and concentration of maprotiline hydrochloride over 2*12 μg ml-1 concentration range. The proposed method was applied for determination of the drug in tablets and the results were compared with those obtained by the official NF XVI method throught t- and F- tests. Keywords :