Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Journal of Research in Pharmacy
2021 , Vol 25 , Issue 2
Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Başıbüyük 34854 İstanbul, Turkey2Department of Pharmaceutical Microbiology, Gulhane Faculty of Pharmacy, University of Health Sciences, Etlik-Keçiören 06018 Ankara, Turkey
3Faculty of Pharmacy, Marmara University, Başıbüyük 34854 İstanbul, Turkey
4Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ankara University, Yenimahalle 06560 Ankara, Turkey DOI : 10.29228/jrp.4 In this study, some N′‑(substituted arylmethylidene)-4‑nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4‑nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS (compounds 3b and 3e) spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N-hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method. Keywords : Sulfonyl hydrazone; hydrazide; MIC; antibacterial activity; quorum sensing