¹Department of Medicinal Chemistry, Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, Lavrentjev av. 9, 630090, Novosibirsk, Russia
²Department of Physical Organic Chemistry, Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, Lavrentjev av. 9, 630090, Novosibirsk, Russia
³Department of Experimental Pharmacology, Research Institute of Clinical and Experimental Lymphology - a branch of the Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Acad. Timakova str., 2, 630060, Novosibirsk, Russia DOI : 10.35333/jrp.2020.136 The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7-diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains (–)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg. Keywords : Actoprotectors; treadmill; bromantane; monoterpenoids; bispidine