¹Department of Pharmaceutics, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Dist – Pune, Maharashtra, INDIA DOI : 10.35333/jrp.2020.143 The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with amphiphilic carrier Soluplus in 1:2 concentration by using solvent evaporation method, solvent melting method and microwave oven method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. These study showed no interaction in drug and carrier. The sublingual tablet represents an innovative drug delivery system, sublingual tablet of lansoprazole was formulated by incorporating selected solid dispersion with combination of novel superdisintegrants and taste maskers like Indion – 414 and Kyron T – 314 by using direct compression method. The sublingual tablet showed the rapid disintegration within average 32 seconds. All the evaluations were performed and complies with the pharmacopoeial standards. The drug and excipient compatibility study of lansoprazole sublingual tablet was also performed by FTIR and DSC. These study showed no interaction in drug and excipients. The formulation F9 (12 % superdisintegrants) showed 98.42% of cumulative drug release within 8 min with zero order release pattern. These novel formulation lansoprazole sublingual tablet showed quick on set of action and may be found to be beneficial, convenient for pediatrics, geriatrics, and psychiatric patients and patients with swallowing difficulties and in situations where water is not available. Keywords : Lansoprazole; sublingual tablet; indion-414; kyron-314; solvent melting