¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turke
²Department of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia
³Medicinal Chemistry & Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science – Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, Andhra Pradesh, India DOI : 10.35333/jrp.2020.110 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal X-ray diffraction study. Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 μg/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity. Keywords : Antimycobacterial; tuberculosis; 4-thiazolidinone; single-crystal X-ray diffraction