ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 2
ANTIOXIDANT AND ANTIHEPATOTOXIC ACTIVITIES OF HEMIDESMUS INDICUS R. BR
G M MOHANA RAO, VENKATESWARARAO, A K S RAWAT, P PUSHPANGADAN, A SHİRWAİKAR
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-Uttarpradesh, India The Antioxidant and antihepatotoxic activities of 50% aqueous ethanolic extract of Hemidesmus indicus R. Br. roots were assessed in experimental animals. In carbontetrachloride induced hepatic challenge in rats, a remarkable elevation of lipid peroxidation and a decrease in liver antioxidant enzymes levels were observed. Pretreatment with the 50% aqueous ethanol extract of Hemidesmus indicus R. Br. roots inhibited these alterations. Based on these results we can suggest that in the liver protective and antioxidative effects of H. indicus, possibly involve mechanisms related to free radical scavenging effects. Keywords : HEMIDESMUS INDICUS; ANTIOXIDANT ACTIVITY; ANTIHEPATOTOXIC ACTIVITY, FREE RADICALS

Istanbul Medipol University