Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 4
Screening of some Sumatran medicinal plants and selected secondary metabolites for their cytotoxic potential against MCF-7 and HSC-3 cell lines
HUSNUNNISA1,Friardi ISMED1,Muhammad TAHER2,Solachuddin Jauhari Arief ICHWAN 3,Amri BAKHTIAR1,Dayar ARBAIN1
1Faculty of Pharmacy/Sumatran Biota Laboratory, Andalas University, Padang, 25163, West Sumatra, Indonesia
2Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia
3Department of Basic Medical Sciences, Faculty of Dentistry, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia
DOI : 10.12991/jrp.2019.186 In continuation of our study of Sumatran plants and bioactivities of their constituents particularly their cytotoxic activities, we re-extracted lichen Stereocaulon graminosum Schaer (Stereocaulaceae), and isolated atranorin (1) and stictic acid (4).. These isolated compounds have been tested for their cytotoxic activities against human breast adenocarcinoma cancer cell (MCF-7) and human oral squamous carcinoma cancer cell (HSC-3) using MTT assay with a slight modification. Some methanolic extracts of the leaves of Elephantopus scaber, Piper betle, Andrographis paniculata, rhizomes of Boesenbergia pandurata, Alpinia galanga, Kaempferia galanga and isolated compounds; ethyl haematommate (2), olivatolic acid (3), deoxyelephantopin (5), andrographolide (6), hydroxychavicol (7), eugenol (8), curcumin (9), pinostrobin (10), pinocembrin (11), alpinetin (12), α-mangostin (13), angiopteroside (14), and stevioside (15) from Sumatran traditional medicinal plants have also been tested. Keywords : Sumatran plants; isolated compounds; cytotoxic; MCF-7; HSC-3
Marmara University