ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 1
EVALUATION OF THE FORMULATION VARIABLES ON THE SWELLING AND THE DISSOLUTION PROPERTIES OF CONTROLLED RELEASE XANTHAN TABLETS OF A WATER-SOLUBLE DRUG
WASFY OBEİDAT, AİMİUT A OBAİDAT
Department of Pharmaceutical Technology, Jordan University of Science and Technology, Irbid, JORDAN Direct compression tablets of xanthan gum containing a water-soluble drug were prepared at different polymer, diluent and drug ratios. An emphasis was directed towards incorporation of large quantities of the model drug. Also, the effects of formulation variables especially tablet excipients on the swelling properties and drug release kinetics were investigated. Swelling studies were conducted using USP disintegration apparatus in deionized distilled water at 37oC. Generally tablets containing high xanthan gum contents show higher rates and degrees of swelling. Drug release studies were conducted using USP XXII dissolution apparatus at 37oC. All tablets showed an extended drug release profile to various extents. Keywords : XANTHAN GUM, CHLORPHENIRAMINE MALEATE, SWELLING, CONTROLLED RELEASE

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