¹Department of Pharmacy, Jashore University of Science and Technology, Jashore-7408, Bangladesh
²Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh DOI : 10.12991/jrp.2019.125 Traditionally Cordyline fruticosa (L.) A. Chev. is being used for the treatment of various disorders, such as fever, headache, diarrhea, coughs, haemoptysis, small pox, madness, skin eruptions, joint pains, rheumatic bone pains, swelling pain and it is also used for abortion. The aim of our study wast o evaluate analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of C. Fruticosa leaves (MCFL). Analgesic effect of MCFL was investigated by using acetic acid induced writhing test, formalin-induced paw licking test, tail immersion test and hot plate test. The anti-inflammatory activity was assessed by using xylene induced ear edema test and cotton pellet induced granuloma test, whereas antipyretic effect was observed by utilizing Brewer’s yeast-induced pyrexia test. In analgesic test, MCFL significantly (∗p< 0.05, vs. control) reduced paw licking and abdominal writhing of mice in a dose dependent manner. MCFL at a dose of 800 mg/kg body weight, significantly increased pain threshold in tail immersion test and hot plate test. Significant anti-inflammatory effect was produced by MCFL by reducing xylene induced air edema and cotton pellet induced granuloma in a dose dependent manner. In anti-pyretic test, after 4th hour of respective treatment, MCFL at all doses exhibited anti-pyretic activity, when compared with control (∗p < 0.05, vs. control). The results obtained demonstrate that C. fruticosa may provide a source of plant compounds with analgesic, anti-inflammatory and antipyretic activities. Keywords : Cordyline fruticosa; analgesic; anti-inflammatory; anti-pyretic