ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 1
DETERMINATION OF MAPROTILINE HYDROCHLORIDE BY ION- PAIR EXTRACTION USING BROMOPHENOL BLUE AND BROMOCRESOL PURPLE
Ş EVRİM KEPEKÇİ, AYSEL ÖZTUNÇ
Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul -Turkey Two simple, rapid, sensitive and accurate spectrophotometric methods are described for the determination of maprotiline hydrochloride in tablets. The methods are based on the reactions of the drug with bromophenol blue (BPB) and bromocresol purple (BCP) in buffered aqueous solutions at pH 3 and 4, respectively to give coloured ion-pair complexes extractable with chloroform. The coloured products are quantitated spectrophotometrically at 411 nm with BPB and 409 nm with BCP. Beer's law is obeyed in the concentration range 2-12 µg ml-1 with both reagents. The proposed methods are applied successfully to the analysis of the drug in its tablet form. Keywords : MAPROTILINE HYDROCHLORIDE, ION-PAIR COMPLEX, SPECTROPHOTOMETRY, BROMOPHENOL BLUE, BROMOCRESOL PURPLE

Istanbul Medipol University