Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2017 , Vol 21 , Issue 4
Development of in situ poloxamer-chitosan hydrogels for vaginal drug delivery of benzydamine hydrochloride: Textural, mucoadhesive and in vitro release properties
1Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06330- Etiler, Ankara, TURKEY
DOI :
10.12991/mpj.2017.3
The use of in situ hydrogel systems for vaginal drug delivery
is an important strategy in the treatment of vaginitis. The
aim of this study was to develop in situ vaginal hyrogels for
benzydamine hydrochloride (BNZ) which were composed of
poloxamer and chitosan. The reason for development of these
hydrogels was to obtain a vaginal delivery system with improved
mechanical and mucoadhesive properties that could provide
prolonged retention time for the treatment of vaginits. The
hydrogels were also designed for once a day dosage of the drug
and to obtain a controlled release of the BNZ. For this purpose
BNZ containing hydrogel formulations using thermosensitive
polymer (Poloxamer 407) and mucoadhesive polymer
(Chitosan H, Chitosan M and Chitosan L) were developed. The
hydrogels are composed of polymers which have promising
potential for vaginal delivery systems. These formulations were
evaluated by rheology, texture, mucoadhesive profiles and drug diffusion with a Franz diffusion cell. It was observed that the
diffusion of BNZ from the in situ poloxamer-chitosan hydrogel
was more sustained and controlled than with the poloxamer gel.
The hydrogel formulations diffused about 65.3±5.1, 80.6±3.8,
88.1±7.3 and 100.4±4.8% of BNZ at 6h. The formulation
containing Poloxamer 407 and Chitosan H has the best
controlled release profile and mucoadhesive properties, results
which indicate that it could suitable for use once a day on the
vaginal route. Moreover, the hydrogels higher mucoadhesion
exhibited by this formulation prolongs the drug residence
time compared with the poloxamer gel and may increase the
BNZ efficacy. These BNZ mucoadhesive vaginal hydrogel
formulations may be a promising alternative to conventional
dosage forms for vaginal topical therapy.
Keywords :
Mucoadhesion; poloxamer; chitosan; hydrogel; benzydamine hydrochloride; vaginal drug delivery