Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2017 , Vol 21 , Issue 4
Alkaloid Profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its Biological Activity
1Department of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100, Izmir, Türkiye2AgroBio Institute, 8 Dragan Tzankov Blvd., 1164-Sofia, Bulgaria
3Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain DOI : 10.12991/mpj.2017.12 The alkaloid profiles of the aerial parts and the bulbs of Galanthus woronowii Losinsk. were analyzed by means of Gas Chromatography-Mass Spectrometry (GC-MS). Totally, twentyeight compounds were detected. Galanthamine and galanthine were found to be the main alkaloids both in the extracts of the aerial parts and the bulbs. Most of the identified compounds were lycorine and galanthamine-type Amaryllidaceae alkaloids. In addition, the acetylcholinesterase (AChE) inhibitor potentials of the extracts prepared from the aerial parts and bulbs were determined by in vitro Ellman"s method and both of the extracts were found to exhibit significant activity (aerial parts: IC50= 0.027 μg/mL and bulbs: IC50= 0.084 μg/mL). Keywords : Galanthus woronowii; Amaryllidaceae; GC-MS; alkaloids