Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2017 , Vol 21 , Issue 2
Potentiometric and Chromatographic Study of Cu(II) and Al(III) Complexes of Quercetin
1Marmara University, Faculty of Pharmacy, Analytical Chemistry Department, İstanbul
DOI :
10.12991/marupj.300814
In this study, the stability constants of the copper(II) and
aluminium(III) complexes of quercetin were determined
potentiometrically by using Calvin-Bjerrum and Irwing Rossotti
methods. The protonation constants of quercetin were found:
logK1 = 11.15±0.118, logK2 = 10.42±0.144, logK3 = 9.44±0.162,
logK4 = 8.28±0.151. For copper complex formation constant
was found by Irwing-Rossotti method: logK1 = 19.92±0.367 and
for aluminium complex complex: logK1 = 23.02±0.459. From
the results, the components of quercetin / metal complexes are given as 1/1 both copper(II) and aluminium(III).A reversed phase high pressure liquid chromatographic method was developed for the metal complexes which were prepared according to potentiometric results with the ratio quercetin / metal =1/1. Mobile phase was 0.01 M HClO4 / 8.33 x 10-5 M quercetin in Methanol (40/60), column was XTerra RP18, 5 μm, 4.6 x 150 mm , detector was Diode Array Detector at λ = 373 ve 421 nm (band width 4nm).
Keywords : Flavonoid-metal complexes, quercetin complexes, biologically active ligands, antioxidants, flavonoids