Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2017 , Vol 21 , Issue 2
Traditional and Alternative Methods For the Evaluation of Eye Irritation Potential of Cosmetic Products
1Hacettepe Üniversitesi, Eczacılık Fakültesi, F.Toksikoloji Anabilim Dalı, Sıhhiye Ankara Türkiye
DOI :
10.12991/marupj.277721
For several years, In vivo ocular toxicity tests were used to
evaluate the hazard potential of drugs and chemicals that are
applied to eye. In ethical terms, eye irritation tests can cause
discomfort and pain in laboratory animals. Since 3R principle
has been published, several alternative methods have been
developed, validated and accepted by regulatory authorities to
evaluate the potential toxicity of chemicals and cosmetics. On
March 11st 2013, the commercial sales of any types of cosmetics
and personal care products tested on animals, were banned in the European Union. Since then, alternative in vitro toxicity
tests are used for the safety evaluation of the cosmetics. For the
evaluation of the ocular toxicity of chemicals and cosmetics,
the In vitro restructured human ocular tissue models are used
as an alternative methods. Some of these models are preferred
more because of their morphological and physiological
similarity to the human eye. In this review, both in vitro
and in vivo ocular toxicity tests will be mentioned; newly
developed and validated test methods will be evaluated with a
comprehensive perspective.
Keywords :
Alternative methods, In vitro, eye irritation, cosmetic products