Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 1
Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application
Md. Masud Kaisar Bhuıyan1, Sujan Banık1, Md. Asif Hasan1, Md. Selim Reza2, Mohammad Salim Hossain1
1Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2Department of Pharmaceutical Technology, University of Dhaka, Bangladesh DOI : 10.12991/marupj.259882 The aim of the study was to investigate the uses of hydrophilic polymers i.e. Methocel K4M and Carbomer 971 to develop a gastroretentive floating drug delivery system containing Carbamazipine as a model drug. The effect of the polymers was evaluated in terms of physical characteristics, swelling properties, floating behavior and drug release profile. Floating lag time was found to be 4-136 sec and total floating time was 6-18 h depending on the formulations. Drug release was studied for 8 h. Simulated drug release pattern in different kinetic model suggests that the mechanism controlling of the drug release from all formulations was the anomalous or non-Fickian. Along with more swelling capacity, carbopol 971 was able to retard the drug release more effectively than that of Methocel K4M based matrix. Keywords : Carbamazepine, Methocel K4M, Carbopol 971, Buoyancy, GRDDS
Marmara University