Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2016 , Vol 20 , Issue 3
Chemical Constituents and Bioactivities From the Leaves of Beilschmiedia Glabra Kosterm (Lauraceae)
1Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia2School of Chemistry and Environment Studies, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) Sarawak, Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia
3Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia DOI : 10.12991/mpj.20162079371 Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α- diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH• radical scavenging, antimicrobial, acetylcholinesterase and lipoxygenase inhibitory activities. Compounds 1 and 2 displayed the strongest lipoxygenase assay with an IC50 value of 5.1 and 5.5 μM, respectively. All compounds showed weak activity on DPPH• radical-scavenging, antimicrobial, and acetylcholinesterase inhibition assays. Keywords : Lauraceae, Beilschmiedia, DPPH•, antimicrobial, acetylcholinesterase, lipoxygenase