¹Faculty of Pharmacy, Department of Pharmaceutics, JNTUA-Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515001, Andhra Pradesh, India
²Professor of Chemistry and Director, Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515001, Andhra Pradesh, India DOI : 10.12991/mpj.20162070534 The aim of present study was to formulate the sustained release floating tablets of Cephalexin (CPL) by direct compression method and optimized by Box-behnken Response Surface Methodology (RSM). A computer aided optimization technique was employed to investigate the formulation design by Boxbehnken RSM (Design Expert Software version 8.0.7.1) to study the effect of the concentration of various polymer blends on the property of CPL gastroretentive floating tablets like floating lag time (FLT ) and cumulative percent drug release (%CDR ). The independent variables investigated were polymeric concentrations (X1) and dependent variables were FLT (Y1), %CDR (Y2) in 0.1N HCl (pH 1.2) buffer. Results from precompression evaluation indicated that all the 17 and optimized formulation F18 were complied with the pharmacopoeial limits and post compression parameters were also gave satisfactory results. The predicted value for FLT and %CDR obtained from software was compared with the experimental value of FLT and %CDR of optimized formulation F18. It was observed that the obtained experimental results for optimized formulation were in very close agreement with the predicted values and also the optimized formulation gave good FLT and %CDR when compared to the 17 formulations. Keywords : Cephalexin; Design Expert Software; Floating tablets; Optimization; Response Surface Methodology