Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2016 , Vol 20 , Issue 2
Genotype and Allele Frequencies of -2841A>T Polymorphism in Glucose Transporter 1 gene in Turkish Population
1Ankara University Institute of Forensic Sciences, Ankara University, Institute of Forensic Sciences, Dikimevi, 06590, Ankara, Turkey
DOI :
10.12991/mpj.20162067368
Glucose transporter 1 (GLUT 1) is located in basolateral side
of cells and mediates the unidirectional transport of glucose
as non-insulin dependent glucose transporter protein. It is
responsible for transportation of glucose especially to cancer
cells and also transports arsenic compounds that is related
with diabetes mellitus. The present study aimed to detect the
allele and genotype frequencies of GLUT 1 -2841A>T single
nucleotide polymorphism (SNP) in Turkish population.
Blood samples were collected from unrelated 100 male and
110 female. Polymerase Chain Reaction (PCR)-Restriction
Fragment Length Polymorphism (RFLP) technique was used to analyze the blood samples. The distribution of -2841A>T
SNP was 55.2%, 38.1% and 6.7% for AA, AT and TT genotype,
respectively. The frequency of the A allele was found as 74.3%
and those of the T allele as 25.7%. The statistical evaluation
represented that the allele frequencies was accordant with
Hardy- Weinberg equilibrium (χ2 =0.002, p=0.97). This was
the first study examining the frequencies of GLUT 1 -2841A>T
polymorphism in Turkish population. In our opinion, these
results can be used in epidemiological studies both in Turkey
and other countries.
Keywords :
Glucose transporter 1; Turkish population; polymorphism; HpyCH4V