ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 3
HYPOLIPIDEMIC EFFECTS OF GARLIC (ALLIUM SATIVUM) AND VITAMIN E IN RABBITS
SYED NAWAZİSH-İ-HUSAİN, ASİM ÖMER, F Z KHAN, MAQSOOD AHMAD, BASHİR AHMAD
Faculty of Pharmacy, University of the Punjab, Lahore, Pakistan The effects of orally administered crude garlic and vitamin E individually and in combination were studied on biochemical parameters of hyperiipidemia in rabbits. AİI the treatments exhibited lowering effect on serum cholesterol, serum low-density lipoproteins (LDL) and serum triglycerides concentrations. The serum high-density lipoproteins (HDL) were boosted to significant levels only by the combination therapy. Vitamin E used alone depicted lipid profile lowering activity in all parameters of the study. The combination therapy markedly increased the cardio- protective lipoproteins HDL which was not significantly raised by the effect of individual drugs. Keywords : ALLIUM SATIVUM, ALLICIN, TOCOPHEROL, HYPOLIPIDEMIC ACTIVITY

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