Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 2
Synthesis and antimycobacterial activity of some 2-(4-aminophenyl)- 5-substituted amino-1,3,4-thiadiazole derivatives and their coupling products
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 34668 İstanbul, TURKEY DOI : 10.12991/mpj.20162013533 In the present study, several 2-(4-aminophenyl)-5-substituted amino-1,3,4-thiadiazoles (2a-l) and their coupling products, 2,3,4-pentanetrione-3-[4-(5-alkyl/arylamino-1,3,4-thiadiazole- 2-yl)phenyl]hydrazones (3a-j) were synthesized in good yields and characterized by UV, IR, 1H-NMR, mass and elemental analysis. Antitubercular activity of the synthesized compounds was determined in vitro using the BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL. The antimycobacterial data of screened compounds indicated that 2-(4-aminophenyl)-5-(4-chlorophenyl)amino- 1,3,4-thiadiazole 2f demonstrated the highest inhibition. Keywords : 1,3,4-thiadiazole, coupling products, antimycobacterial activity
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