¹Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
²Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
³Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran DOI : 10.12991/mpj.20162085639 Food allergy includes an overreaction of the immune system to certain foods or substances that trigger the immune system become confused. The purpose of this study was to evaluate the effect of oral administration of plantain leaf extract on immunity against food allergies in dogs. This study performed on 12 dogs and the dogs were divided into 3 groups. In 3 groups, 2 times a day for 5 days 10 grams of turmeric tablet was administered to food allergies occur in all categories. To first group twice daily, for 5 days, in each time 100cc oral plantain extract administered. In second group, prednisolone acetate used instead of plantain extract for 5 days (according to the dose of 2 mg/kg every 24 hours). And in third group (control) no medication used. Blood samples took for hematology and immunology experiments at days 0, 5 and 10 and the amount of blood was divided into two equal parts, and for hematology tests and to measure IgE immune factors and percentage and number of phagocytosis was sent to faculty lab. The result showed that in three groups comparison, during the recovery (post- treatment), eosinophils (Eos), immunoglobulin E (IgE) and germ amount in Leaf extract group has no significant change in appropriation to control group. The amount of these factors in comparison with the chemical drug group (Corton) had significant change (p<0.05), and other factors did not change significantly during treatment (p<0.05). Moreover, comparing two groups of Corton and sycamore, there is significantly better changes in IgE and Eos factors in the plantain leaves group. Therefore, mentioned factors indicate a favorable effect of plantain leaf extract in removing the symptoms of food allergy in dogs. Keywords : Corticosteroids, Dog, Food allergy, Immune system, Plantain leaf extract