Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2014 , Vol 18 , Issue 3
Synthesis and larvicidal and adult topical activity of some hydrazidehydrazone derivatives against Aedes aegypti
Kadriye AKDAG1, Bedia KOCYIGIT-KAYMAKCIOGLU1, Nurhayat TABANCA2, Abbas ALI2, Alden ESTEP3, James J. BECNEL3, Ikhlas A. KHAN2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 34668, Istanbul, Turkey
2Center for Natural Products Research, The University of Mississippi, 38677, Mississippi, USA
3USDA, ARS, Center for Medical, Agricultural and Veterinary Entomology (CMAVE), Gainesville, FL 32608, USA
4Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, Mississippi, USA
5Navy Entomology Center of Excellence, NASJAX, Jacksonville, Florida, USA
DOI : 10.12991/mpj.2014187238 A series of novel hydrazide-hydrazone derivatives were synthesized and evaluated for their larvicidal and adult topical activity against Aedes aegypti. The proposed structures of all the synthesized compounds were confirmed using elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Compounds 4a-h were screened in larval bioassays at concentrations of 100, 50 and 25 ppm in a dose dependent manner and data for their mortality was recorded. Among the tested compounds, 1-(4-nitrophenyl)-3-(4-{2-oxo-2-[2-(2-oxo-1,2-dihydro-3H-ylidene)hydrazinyl] ethyl} phenyl)urea (4b) showed noteworthy larvacidal activity against Aedes aegypti. Dose-response data of compound 4b showed LC50 and LC90 values of 30.5 (15.4 – 22.7) and 95.9 (73.8 – 139.4) ppm, respectively. Screening of compounds 4a-h at four doses by topical bioassay indicated a range of activity between 10000 and 1000 ppm. Keywords : Hydrazide-hydrazone, mosquito control, Aedes aegypti, larvicidal activity, adult topical activity
Marmara University