Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2014 , Vol 18 , Issue 2
The Evaluation of Salivary Thromboplastic Activity of An Acute Lymphoblastic Leukemia (ALL) Case During Treatment
Tiraje CELKAN1, Aysen YARAT2, Tugba TUNALI AKBAY2, Serap Akyüz3, Rabia PISIRICILER4, Inci YILDIZ1
1İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Pediatrik Hematoloji- Onkoloji Ana Bilim Dalı, Cerrahpaşa, İstanbul, Türkiye
2Marmara Üniversitesi, Dişhekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, Biyokimya, Nişantaşı (34365), İstanbul, Türkiye
3Marmara Üniversitesi, Dişhekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, Pedodonti, Nişantaşı (34365), İstanbul, Türkiye
4Marmara Üniversitesi, Dişhekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, Histoloji ve Embriyoloji, Nişantaşı (34365), İstanbul, Türkiye DOI : 10.12991/mpj.2014186121 Oral cavity is a region where various mucosal lesions and infections occur. Saliva has an important role in the protection of oral cavity. Cancer and its treatment lead to several changes in oral cavity including the changes observed in saliva composition. These can affect the healing process of the oral wounds and the incidence of tooth decay. Thromboplastin (tissue factor, FIII) is a membrane bound glycoprotein and it is involved in the wound healing processes. In the present study, saliva samples were taken from an acute lymphoblastic leukemia (ALL) case at different times and were examined both biochemically and cytologically. According to the findings of this study, salivary pH differences and the increase in susceptibility to infections in the oral region may have caused the formation of mucositis and ulceration and the decrease in thromboplastic activity.

We believe that early detection of infection in the oral cavity and accordingly its treatment is important in terms of patient"s life quality. Keywords : Acute lymphoblastic leukemia, salivary thromboplastic activity, salivary pH

Marmara University