METHODS: In this research work chitosan based chitosan-moxifloxacin conjugates have been successfully formulated by using distilled water and glacial acetic acid mixture and the film was made by solution casting method. Formulated films were characterized by various analytical methods such as UV, IR and DSC as well as biological methods.
RESULTS: The antibacterial activity of chitosan-moxifloxacin conjugates was tested against various microorganisms viz, gram positive bacteria"s Streptococcus pneumoniae and Staphylococcus aureus and the results indicated that the antibacterial activity of chitosan-moxifloxacin conjugates was several time greater than that of parent drug moxifloxacin. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugates.
CONCLUSION: This proposed combination may result in the enhancement of the separate activities of chitosan and moxifloxacin.
Keywords : MFX (Moxifloxacin), CH (Chitosan), conjugate, prodrug, electrostaticinteraction, antimicrobial etc