Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2013 , Vol 17 , Issue 3
Development of a New and Efficient Synthesis Method of 1,2,4-Triazole-5- Thione Derivatives
Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey
DOI :
10.12991/2013171313
3,4-Disubstituted-2,4-dihydro-5H-1,2,4-triazole-5-thiones were synthesized by a
new one-pot, two-step synthesis method which was demonstrated to be superior than the
current synthesis methods. The new method involves addition of alkyl/aryl isothiocyanates
to substituted hydrazides in ethanol following the refluxing process of intermeadiate in 4N
sodium hydroxide solution. According to our new synthesis procedure, reaction has gone to
completion within 6 hours by higher product yields and reduced solvent usage.
Keywords :
1,2,4-triazole-5-thione, synthesis, method development