Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2012 , Vol 16 , Issue 3
Synthesis, characterization and antiviral evaluation of 1,3-Thiazolidine-4-one derivatives bearing L-Valine side chain
Esra Tatar1, İlkay Küçükgüzel1, Erik De Clercq2, Ramalingam Krishnan3, Neerja Kaushik-Basu3
1Marmara University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, İstanbul, Turkey
2Katholieke Universiteit, Rega Institute for Medical Research, Leuven, Belgium
3UMDNJ-New Jersey Medical School, Department of Biochemistry and Molecular Biology, Newark, USA
DOI : 10.12991/201216398 1,3-Thiazolidine-4-ones have been known to possess anti-HIV and anti-HCV activity as they are, respectively, HIV-1 non-nucleoside reverse transcriptase inhibitors and HCV NS5B RNA-dependent RNA-polymerase inhibitors. Some novel 1-[2-(benzoylamino)- 3-methylbutyryl]-4-alkyl/arylalkylthiosemicarbazides, 2-[2-(benzoylamino)-3-methylbutyrylhydrazono]- 3-alkyl-/arylalkyl- 5-non substituted/methyl-1,3-thiazolidinones, were synthesized and evaluated for their antiviral activity. Antiviral activity of the synthesized compounds were screened against various types of viruses (Feline Corona Virus (FIPV), Feline Herpes Virus, HSV-1(KOS), HSV-1(TK-KOS ACVr), HSV-2(G), Vaccinia virus, Vesicular stomatitis virus, Varicella- ZosterVirus TK+VZV, Varicella-ZosterVirus TK-VZV, Cytomegalovirus, Respiratory syncytial virus, Coxsackie B4 virus, Parainfluenza-3 virus, Reovirus-1, Sindbis virus and Punta Toro virus) in CRFK, HEL, HeLa and Vero cell cultures. Anti-HIV and cytotoxicity data were also obtained with the compounds using the strains HIV-1 (IIIB) and HIV-2 (ROD) in an MT-4/MTT based assay. None of the tested compounds showed antiviral activity at subtoxic concentrations. For all the synthesized compounds anti-HCV NS5B RdRp activity was not observed at the concentration of 100 μM which was the highest concentration tested. Keywords : 4-Thiazolidinones, L-valine, anti-HIV activity, anti-HCV activity
Marmara University