Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
2012 , Vol 16 , Issue 1
Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
1Ege Üniversitesi, Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı, İzmir, Türkiye2Ege Üniversitesi, Eczacılık Fakültesi Analitik Kimya Anabilim Dalı, İzmir, Türkiye DOI : 10.12991/201216420 In this study, synthesis and determination of interaction between DNA and 1Hbenzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA – drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively. Keywords : 1H-benzimidazole, electrochemical genosensor, DNA-drug interaction, synthesis