ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 2
MICROSPHERES OF VERAPAMIL HYDROCHLORIDE: A NOVEL APPROACH FOR GASTRIC RETENTION USING HYDROXYPROPYL METHYLCELLULOSE
PATEL MANİSH, PATEL JAYVADAN, PATEL RAVİ, PATEL KALPESH, THAKOR RASHMİN
Nootan Pharmacy College, Visnagar, Gujarat, India The aim of present investigation was to prepare and evaluate gastroretentive floating microspheres of verapamil hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time. Floating microspheres were prepared by emulsion solvent evaporation technique. In the present investigation three polymers were used in various concentrations; Methocel K4M, Methocel K15M and Methocel K100M. In vitro performance was evaluated by the usual pharmacopoeial and other tests such as particle size analysis, drug entrapment efficiency, flow properties, in vitro floatability studies, in vitro drug release studies and stability studies. Results showed that the mixing ratio of components in the organic phase affected the size, size distribution, yield, drug content, floating time and drug release of microspheres. In most cases good in vitro floating behavior was observed and a broad variety of drug release pattern could be achieved by variation of the drug, polymer and solvent ratio. Keywords : FLOATING MICROSPHERES, VERAPAMIL HYDROCHLORIDE, IN VITRO RELEASE

Istanbul Medipol University