Piroxicam, a nonsteroidal antiinflammatory drug, has analgesic and antipyretic affects. Because of these effects in this study. We investigated the effect of piroxicam on some biochemical parameters. Rats weighing 180 - 200g were divided into two as experimental and control groups Serum physiologique was injected intraperitoneally every day to the control group for 15 days. At the end of 15 days, blood samples have been taken from the rats and urea,uric acid, creatinin, LDH, N⁺, K⁺, Cl- , SGOT, SGPT and GGT quantity determinations have been accomplished. When 1 mg kg piroxicam injected experimental group has been compared with the control group, no significant difference has been observed. In the experiment group which 2 mg/ kg piroxicam has been injected, significant increase has only been observed in serum GGT level (p<0.001). Keywords :