Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1995 , Vol 11 , Issue 1 - 2
Phytochemical studies on Platycodon grandiflorum (JACQ) A. Introduced in Bulgaria
Nguyen Thuan,Stefan Nikolov
Platycodon grandiflorum (Fam Campamılaceace) is widely used as an expectorant and antiinflammatory drug in the traditional and folk medicine of the East-Asian subcontinent of which it is native , whereas it is not well known in Europe. It has now been introduced in Bulgaria, and therefore, became the object of our phytochemical investigations mainly for the saponins and flavonoids. All the investigated parts of the plant (roots,stems and leaves) contain saponins with H1>1000. By the TLC methods 5 pentacyclic triterpenoid saponins were established in the roots. In the herb of plant, 8 flavonoids and 4 phenolic acids were established by PC By CC method and preparative PC, 3 flavonoids and one phenolic acid have been isolated in pure state. They are - luteolin -7-O-D-glucoside, luteolin and chlorogenic acid. They were identified by the determination of their m.p.s, UV spectras, acid hydrolysis and PC comparison with authentic samples in different solvent systems. The last three compaunds have identified for the first time from the species. Keywords : Platycodon grandiflorum, saponins, flavonoids, flavone glycosides
Marmara University