In this work the protein distribution was examined in the tumoral and normal parts of the colon tissue of colon cancer patients. The protein fractions were isolated either by percholoric acid precipitation (cases : 1_8) or by ammonium sulphate precipitation (cases :9_10). These protein fractions were analyzed by SDS-PAGE. CEA levels were determined and CEA was detected both in the normal and cancerous parts. The protein fractions of the cases 9 and 10 were also analyzed with isocratic HPLC. Protein pead with Rts 11⁶⁰ and 12⁰⁰ were observed in the tumoral and samples, respectively. Keywords : Colon adenocarcinoma and antigens, colonic carcinoma, colon cancer, carcinoembryonic antigen, colorectal carcinoma