Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1985 , Vol 1 , Issue 1 - 2
Reductive cleavage of azo compounds with hydrazine hydrate and some new 1, 3, 4-thiadiazole derivatives
Sevim Rollas
In this study, the azo groups of 2-aryl/alkylamino 5*[p-(1’-phenyl-3’,5’-dimethyl-4’pyrazolylazo)-phenyl]-1,3,4-thiadiazoles which were previously prepared by us were reduced with hydrazine hydrate without a catalyst in ethanol and the following compounds were obtained: 2-n-propylamino-5[p-aminophenyl]-1,3,4-thiadiazole (I), 2-n-buthylamino-5[p-aminophenyl]-1,3,4-thiadiazole (II), 2-cyclohexylamino-5[p-aminophenyl]-1,3,4-thiadiazole (III), 2-phenetylamino-5[p-aminophenyl]-1,3,4-thiadiazole (IV), 2-phenylamino-5[p-aminophenyl]-1,3,4-thiadiazole (V). The structures of these substances were elucidated using UV, IR and NMR spectral methods besides elementary analysis. Keywords :
Marmara University