This study is intended to evaluate the trends of antidiabetic drugs utilisation in Buşgaria for assesing the cost of the therapy. The comparative analysis between morbidity data and drug consumption data has been developed and the cost- minimisation analysis for the economic assesement has been used.The results show that for the last four years there are increasing data for national and regional antidiabetic drugs consumption, especially for human insulin and for North regions. They correspond with increasing morbidity data from diabetes in the country. The most expensive therapy has been found for the insulin dependent patients. Keywords : drug utilisation, diabet morbidity, pharmacoeconomics