Antibiotic (AB) consumption in Bulgaria during the year 1992 as compared with 1989 has been evaluated by the method of Defined Daily Doses (DDDs). An increase of 16.6% for the total antibiotic consumption for 1992 has been found as compared with 1989. Antibiotics of the J01C group- Beta-lactam antibacterials and penicillins show nearly three fold increase with Amoxacillin (Amopen) on the first place in the list of the AB use - DDD 44,5 (1992). A substantial increase in the J01D-A Cephalosporins and other related substances and J01F a Macrolides also has been registered. On the contrary the use of J01E Sulfonamides and Trimetoprim has decreased - nearly by 87%. The need of monitoring the AB utilization in Bulgaria according the World Health Organization recommendation is discussed. Keywords : DDDs, pharmacoeconomics, ATC classification, drug sale, antibiotic utilization