Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1985 , Vol 1 , Issue 1 - 2
Determination of procainamide hydrochloride and some dosage forms with 9-chloroacridine by quenching fluorometry
Sezen İslimyeli
A fluorometric method was developed for the analysis of procainamide hydrochloride and some dosage forms. The method is based on the reaction of procainamide hydrochloride with 9-chroroacridine at pH 3. This interaction results in quenching of native fluorescence of the 9-chloroacridine reagent solution. The fluorescence measurements were performed at activation and emission wavelengths of 9-chloroacridine (400 and 437 nm respectively). The fluorescence intensity is linear over the concentration range 40-800 ng/ml procainamide hydrochloride. The method was applied to marketed dosage forms and the results were compared statistically with those of USP XVIII, TF 1974, and p-dimethylaminocinnamaldehyde methods in respect to t and F tests of significance. Keywords :
Marmara University