¹Department of Pharmaceutics, Faculty of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
²Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
³Student research committee, Faculty of pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran DOI : 10.29228/jrp.2022.00 Levofloxacin is a broad-spectrum antibacterial drug belonging to the third generation of fluoroquinolones. The project aims to develop a novel microemulsion system for effectively delivering levofloxacin to the eye. In addition, this study assessed the physical and chemical characteristics of a substance and its ability to permeate through the eyes of rabbits. The microemulsions (MEs) were evaluated for stability, drug release, viscosity, pH, particle size, and cornea permeability in rabbits. This study employed a three-variable design with two levels to prepare eight samples and analyze data. Based on research results, ME formulations had an average size ranging between 8.52 and 25.2 nm and a pH range of 4.45 to 6.01. Content viscosity ranged from 170-400 cps, and based on the drug release curve, 89.49% of the medicinal product was released within the first day of the trial. Drug sensitivity in rabbit cornea was highest in ME-LEV-5 (50.89%) and lowest in ME-LEV-7 (23.78%). This study demonstrates how the physical properties and permeability of the drug during drug penetration of ME formulations can be modified by changes in the quantity and quantity of ME. This phenomenon may be due to changes in the corneal structure caused by different ME components. Keywords : Corneal Permeability; Microemulsion; Levofloxacin; Rabbit, drug delivery