¹Department of Pharmaceutical Analysis, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana-500001, India
²Department of Pharmacognosy, Shadan College of Pharmacy, Peerancheru, Hyderabad, Telangana-500091, India
³Department of Pharmaceutical Analysis, Bojjam Narasimhulu Pharmacy College for Women, Hyderabad, Telangana 500059, India DOI : 10.29228/jrp.2022.00 Nanotechnology is among the most developing aspects of the medical stream. Gum acacia (GA), being biocompatible, naturally occurring, non-toxic, and inexpensive polymer, has gained tremendous attention in the field of pharmacy. The nanoparticle production using Gum acacia as a template led to more stable drug delivery systems. Zinc oxide (ZnO) and Titanium dioxide (TiO2) possess potential biological applications including anticancer activity, antimicrobial activity, bioimaging, and potent drug carrier properties. The synthesis of Gum acacia stabilized Zinc oxide and Titanium dioxide nanoparticles incorporated with Entacapone an antiparkinsonian drug, was carried out keeping in view all these aspects. Entacapone is a combination of drug therapy with levodopa and carbidopa in the treatment of Parkinson’s disease (a neuro-degenerative disorder). The synthesized drug – nanocomposite showed extended release or sustained-release properties. According to the experimental results, it is reported that the Gum acacia along with ZnO and TiO2 acts as a drug delivery carrier releasing Entacapone at the intended site in desired time and quantity. Keywords : Nanoparticles; Drug delivery carrier; Sustained release; Entacapone; Anti-parkinsonian drug