¹Department of Public Health, Faculty of Medicine, Universitas Prima Indonesia, Medan 20118, North Sumatra, Indonesia
²Faculty of Medicine, Maranatha Christian University, Bandung 40164, West Java, Indonesia
³Biomolecular and Biomedical Research Canter, Aretha Medika Utama, Bandung 40163, West Java, Indonesia
⁴Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, West Java, Indonesia DOI : 10.29228/jrp.2022.00 Aging is a skin phenomenon that is caused intrinsically by tissue degeneration and extrinsically by environmental toxicity including ultraviolet (UV) exposure, manifested as wrinkles and skin damage respectively. Chlorogenic acid (CA) possesses roles as antiinflammation and antioxidation by reducing reactive oxygen species (ROS). The present study examined CA anti-aging activities toward skin fibroblast (BJ) cells induced by UV. Antiaging properties of CA were analyzed by assessing the levels of collagen-1α1 (COL-1α1), elastin (ELN), 8-hydroxy 2 deoxyguanosine (8-OHdG), melatonin (MT), and hyaluronidase (HAase), and by quantifying the percentages of living cells, dead cells. CA treatment on aging cells diminished the 8-OHdG, HAase, and a percentage of apoptotic cells. It also improved the levels of COL-1α1, ELN, MT, and the proportion of living cells. This study proved CA ability as an antiaging agent through its roles as a free radical scavenger and anti-apoptotic agent. Keywords : antiaging; chlorogenic acid; fibroblast; skin; UV