¹Chemistry department, College of Science, Mustansiriyah University, Baghdad- IRAQ
²College of Medicine, Mustansiriyah University, Baghdad- IRAQ DOI : 10.29228/jrp.2022.00 Number of women with polycystic ovary syndrome (PCOS) who have an insulin resistance at the same time was increased to large numbers in Iraq, with a lack of statistics regarding the number of PCOS patients and the role of some of biochemical variables that may interfere and causing this disease. The research aimed to study the levels of some trace elements namely; lead, nickel, iron, manganese and cobalt in the serum of Iraqi PCOS patient in a case control study in which the serum Pb, Ni, Fe, Mn and Co concentrations were determined in sixty women with PCOS with an age ranged from 20-40 years old and compared with those levels in 60 age, gender, and BMI-matched healthy volunteers selected as a control group which showed that the levels of Lead and nickel were significantly higher (p<0.05) in the levels of Fe, Mn and Co in patients comparing with controls. The analysis of the ROC curve analysis revealed that all studied trace elements provide significant results with highest values of AUC, sensitivity and specificity obtained with Ni which is 0.954, 85% and 98.3% respectively and in Mn of 0.908, 86.7 % and 88.3 % respectively which indicate that these elements can be considered as good predictive markers for PCOS. Keywords : PCOS; Lead; Nickel; Manganese; Iron; Cobalt