¹Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, University of AlKafeel, Najaf, Iraq. 54001
²Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq. 52001 DOI : 10.29228/jrp.886 The present study involved the preparation of Zein/Poly (Ɛ-caprolactone)/Poly (ethylene oxide) (Zein/PCL/PEO) nanofiber loaded with silver sulfadiazine (SSD) using the electrospinning process. These Nanofibers were intended for topical medication delivery applications to increase the drug delivery rate and minimise application times. In the present study, silver sulfadiazine was initially introduced into (Zein/PCL/PEO) nanofiber. The characterisation of nanofiber mat involved using Attenuated Total reflective Infrared Spectroscopy (FTIR) to assess the chemical interaction between SSD and the polymer matrix. The Scanning Electron Microscopy (SEM) technique was employed to study the surface morphology of the nanofibers. To improve the solubility, effective drug release, and efficient drug loading of SSD, composite nanofiber carriers consisting of (Zein/PCL/PEO) were electrospun by the identification of best formula using Design Expert® software, X-ray diffraction analysis (XRD) was used to identify the crystalline state of the pure SSD, (Zein/PCL/PEO) polymers and SSD loaded (Zein/PCL/PEO) nanofibers selected adsorbent. The scanning electron microscopy (SEM) photos demonstrated the successful production of composite nanofibers that exhibited a consistent and smooth surface morphology. The nanofibers' diameter decreased upon introducing SSD and the findings of many experimental outcomes have consistently indicated that composite nanofibers consisting of (Zein/PCL/PEO) loaded with SSD exhibit significant promise for topical medication delivery applications. Keywords : drug delivery systems; silver sulfadiazine; Poly (Ɛ-caprolactone); nanofiber matrix; Poly (ethylene oxide)