¹Department of Pharmaceutical Botany, Faculty of Pharmacy, Marmara University, İstanbul, Turkey DOI : 10.29228/jrp.2022.00 This paper presents important ethnobotanical information about the folk-medicinal plants found in Kartepe and their ethnopharmacological usage. The primary aims of the study were collecting and identifying plants used therapeutically by the local people, and making available traditional, herbal medicinal information about these plants. The study, conducted from 2018 to 2019, is based on plants collected during field work. The study identified 59 plants that are used in folk-medicine and that belong to 31 families. Of these, 47 taxa were wild, and 12 species were cultivated plants. The most common families were Rosaceae (14%), Asteraceae (12%), Malvaceae (7%), Lamiaceae (5%) and Papaveraceae (5%). The most common preparation was infusion (30.9%). In addition, a cultural importance index (CI) was calculated for each species. Based on the CI, the most important plants were Hypericum perforatum (0.82), Plantago major subsp. major (0.80), Ficus carica subsp. carica (0.79) and Chelidonium majus (0.77). Thus, with this study, the plants used as folk medicine in the region have been scientifically identified and a resource has been created to transmit this information to future generations. Keywords : Ethnobotany; Folk medicinal plants; Kartepe; Kocaeli; Turkey