¹İstanbul Rumeli University, Faculty of Sport Sciences, 34744 İstanbul, Türkiye
²Düzce University, Faculty of Sport Sciences, 81620 Düzce, Türkiye
³University of Health Sciences, Faculty of Pharmacy, 06018 Ankara, Türkiye
⁴Karadeniz Technical University, Faculty of Pharmacy, 61080 Trabzon, Türkiye
⁵Experimental Animals Laboratory of Düzce University, 81620 Düzce, Türkiye DOI : 10.29228/jrp.2022.00 The aim of this study is to determine the protective effects of lupeol on acute exhaustive exercise-induced oxidative stress in male rats. Rats were randomly selected and divided into four groups (n=6/group): Control, exercise, lupeol and exercise+lupeol groups. At the end of the exercise protocol, the rats were sacrificed by cervical dislocation, blood samples were taken. The levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), coenzyme Q10 (CoQ10) and α-lipoic acid (ALA) and oxidative stress levels in serum samples were measured. As a result, it has been determined that lupeol, a natural triterpenoid compound, contributes positively to the level of antioxidants produced by the body and helps suppress oxidants. It has been observed that free radicals caused by oxidative stress that occur as a result of high-intensity exercise are reduced by lupeol. Accordingly, it has been determined that the use of lupeol during exercise in experimental animals exposed to oxidative stress inhibits free radicals formed by stress. In the light of these results, it is thought that lupeol may be included in the composition of pharmaceutical products against exercise-induced oxidative damage. Keywords : Antioxidant; exercise; free radical; lupeol; oxidative stress