¹Undergraduate Student Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
²Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia DOI : 10.29228/jrp.2022.00 Facial masks are often used for the prevention of skin damage, such as skin aging due to free radical activity. The peel-off gel mask is convenient because it can be easily removed after drying without rinsing. Free radical activity can be inhibited by using antioxidants. One of the antioxidants can be derived from natural materials such as binahong. This study aimed to optimize the peel-off gel mask formula containing binahong leaf extract and evaluate the antioxidant activity of the gel mask formula during the storage period. Peel-off gel masks were prepared by combining PVA, CMC-Na, and sodium alginate as gelling agents. A simplex lattice design (SLD) method was used to optimize the peel-off gel mask formula. The optimum formulation was obtained using a combination of 3.5 g PVA, 1.5 g sodium alginate, 5 g propylene glycol, and 0.1 g potassium sorbate. The optimum formulation has an average spreading capacity of 9.2 ± 0.21 cm, adhesion capacity of 1.09 ± 0.33 seconds, viscosity level of 1491.67 ± 10.78 cP, pH of 7.21 ± 0.02, a drying time of 68 ± 6.24 min, tensile strength of 1.792 ± 0.25 MPa, elongation of 68.077% ± 1.14, and antioxidant capacity with inhibition percentage of 55.087% ± 2.87. The peel-off gel mask containing binahong leaf extract meets the good criteria as the peel-off gel mask. Moreover, the characteristics of the optimal formula peel-off gel mask did not change significantly for 4 weeks of storage at 40oC ± 2oC/75%RH ± 5%RH. Keywords : Peel-off gel mask; binahong; PVA; alginate; CMC