¹Department of Pharmacology, Sri Shanmugha College of Pharmacy, Affiliated to the Tamilnadu Dr. M.G.R. Medical University, Salem, Tamil Nadu 637302, India
²Department of Pharmacology, KMCH College of Pharmacy, Affiliated to the Tamilnadu Dr. M.G.R. Medical University, Coimbatore, Tamil Nadu-641048, India
³Senior Research Associate, Syngene International Limited, Biocon Park, Bengaluru, Karnataka-560099, India
⁴Department of Pharmacognosy, KMCH College of Pharmacy, Affiliated to the Tamilnadu Dr. M.G.R. Medical University, Coimbatore, Tamil Nadu-641048, India DOI : 10.29228/jrp.860 Pergularia daemia is one of the medicinal plants traditionally used for the management of asthma. The current study evaluated the anti-asthmatic activity of aerial parts of Pergularia daemia in ovalbumin-induced asthma in BALB/c mice, histamine induced bronchospasm in guinea pigs, and compound 48/80 induced mast cell degranulation in rat peritoneal mast cell. Administration of ovalbumin in BALB/c mice has significantly increased total leukocyte count, infiltration of inflammatory cells, and altered the levels of in vivo anti-oxidant enzymes such as glutathione, catalase with the elevation of lipid peroxidation and total protein. Treatment with the methanolic extract of Pergularia daemia significantly reduced the total leukocyte count, elevated inflammatory cells, lipid peroxidation, and total proteins, and restored the altered levels of glutathione and catalase. The onset of Pre convulsion Dyspnea in guinea pigs was significantly increased on treatment with the methanolic extract of Pergularia daemia. Further, the methanolic extract of Pergularia daemia exhibited significant protection against compound 48/80 induced mast cell degranulation in rat peritoneal mast cells. Keywords : Guinea pig; compound 48/80; histamine; BALB/c; ovalbumin