Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Journal of Research in Pharmacy
Articles in Press
Evaluation of anti-diabetic potential of Ficus arnottiana Miq. leaves against in-vivo and in-vitro experimental models of diabetes
1HKES’s Matoshree Tradevi Rampure Institute of Pharmaceutical Sciences, Kalaburgi, 585105,Karanataka, India2Department of Pharmacology, Faculty of Pharmacy, Maulana Azad University, Village Bujhawar, Tehsil Luni, Jodhpur 342008, Rajasthan, India
3Department of Pharmaceutics, College of Dentistry and Pharmacy, Buraydah Private Colleges, Buraydah, Al- Qassim 31717, Kingdom of Saudi Arabia
4Deccan School of Pharmacy, Darussalam, Hyderabad-500001
5Pharmacy College Saifai, UPUMS Saifai, Etawah, 206130, Uttar Pardesh, India
6Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, City Dammam, Saudi Arabia
7Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Quest International University, Ipoh, Perak, Malaysia
8Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Maulana Azad University, Village Bujhawar, Tehsil Luni, Jodhpur 342008, Rajashthan, India DOI : 10.29228/jrp.2022.00 The present study was aimed to investigate the potential anti-diabetic effects of Ficus arnottiana Miq. leaves against streptozotocin-induced diabetic model in experimental animals. The leaves of Ficus arnottiana were collected and processed into a powdered form, which was subsequently extracted using methanol as the solvent. The anti-diabetic activity of the resulting extract was evaluated at two oral doses (200 and 400 mg/kg) at two different doses (200 and 400 mg/kg). The parameters assessed in this study included blood glucose levels, C-peptide levels, and serum insulin levels. Furthermore, pancreatic tissue samples were subjected to histopathological analysis. Additionally, in vitro determination of a-amylase and a-glucosidase inhibition by the extract was carried out. The phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, reducing sugars, and saponins. For anti-diabetic activity, the test extract significantly reduced blood glucose levels while increasing both serum C-peptide and serum insulin levels. Histopathological analysis of extract treated group depicted improved islets of Langerhans and an increase in centrally located beta cells. Furthermore, the extract significantly inhibited a-amylase and aglucosidase enzyme in-vitro. Based on these findings, it can be concluded that Ficus arnottiana (Miq) leaves extract exhibits antidiabetic activity. And the anti-diabetic effect of Ficus arnottiana (Miq) at 400 mg/kg was comparable to that of the standard drugs Glibenclamide (in-vivo) and acarbose (in-vitro). Keywords : Anti-diabetic activity; STZ induced diabetes; histopathological evaluation; α-amylase; α-glucosidase; Ficus arnottiana (Miq)