¹Department of pharmaceutics, HanagalShriKumareshwar College of Pharmacy, Bagalkote, Karnataka, India
²Department ofpharmacology, HanagalShriKumareshwar College of Pharmacy, Bagalkote, Karnataka, India DOI : 10.29228/jrp.820 The aim of present work is to formulate and characterize the Vildagliptin (VLD) loaded polymeric nanoparticles for the treatment of type II diabetes mellitus. Polymeric nanoparticles were prepared by ionotropic gelation method with sodium tripolyphosphate (STPP) as a cross linkers. The obtained sample of VLD was evaluated by UV and FT-IR studies. Prepared polymeric nanoparticles were characterized in term of drug-polymer intraction, particle size and polydispersity index (PDI), zeta potential, % drug content (DC), % drug entrapment efficiency (DEE) and scanning electron microscopy (SEM). In vitro and in vivo drug release studies were also performed. FT-IR study showed that drug and polymers are compatible with each other and cross-linking was observed between chitosan and STPP. Particle size was range from 238.2 nm to 708.8nm for all the formulations. Zeta potential was range from-8.49mV to 11.1mV. %DC range from68.12% to 84.37%, and % DEE was range from 78.76% to 93.91%. SEM images showed that the prepared formulations were smooth and spherical. In vitro drug release evaluation in phosphate buffer pH 7.4 showed sustained release pattern, i.e. 55.17% to 62.89% within 12hours. The data were fitted to Korsmeyer-Peppas model which showed fickian diffusion as a predominant release mechanism. In vivo drug release evalutionshowed significant decrease in the blood glucose level. Thus, conclude that prepared polymeric nanoparticles by ionotropic gelation method have a sustain release pattern and incresesstabilty of drug. Keywords : Vildagliptin; Chitosan; STPP; Ionotropic gelation method; Polymeric nanoparticle; anti diabetic activity