Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2024 , Vol 28 , Issue 5
Phytochemical analysis and antifungal activity propolis Lombok against Candida sp and Cryptococcus sp
Shabrina NUBLA1,Robiatul ADAWIYAH2,Muhamad SAHLAN1,Mulyati TUGIRAN2,Ni Made Candra WIDYANTARI6,Chastine HARLIM6
1Faculty of Engineering, University of Indonesia, Depok, Indonesia
2Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
3Study Program of Clinical Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
4Master Program in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
5Research Centre Biomedical Engineering, Faculty of Engineering, University of Indonesia, Depok, Indonesia
6Undergraduate Program, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia DOI : 10.29228/jrp.817 Fungal infections become a serious problem, especially in developing countries. Antifungal drug classes that have developed shows some limitation due to poor selectivity, toxicity, and high resistance. Propolis is a natural resinous substance from flower buds, trees, and resinous exudates collected by bees. Propolis has several therapeutic properties such as antibacterial, anti-inflammatory, antifungal, and antiviral. This study explores antifungal activity of Ethanolic Extract of Propolis (EEP) Lombok against Candida albicans, Candida glabrata, Candida krusei, and Cryptococcus neoformans. Antifungal activity test were carried out with 2 different methods, agar diffusion and microdilution to see EEP Lombok’s ability to inhibit fungal growth. In addition, this study analyzes phytochemical contents of Propolis Lombok by characterizing its substance and calculating the total phenolic content. The result shows the total polyphenol content of Lombok’s EEP is around 222-278 mgGAE/g meanwhile total polyphenol content is 512-1100 mg QE/g. Based on the antifungal tests, propolis samples showed antifungal activity against C. albicans, C. glabrata, C. krusei, and Cryptococcus neoformans species. Propolis Lombok agar diffusion test showed an inhibition growth against C. albicans, C. glabrata, and C. krusei. While for microdilution test, propolis extract only affects C. albicans, C. glabrata, and Cryptococcus neoformans growth. Keywords : Propolis; Antifungal; Phytochemical Analysis; Candida sp; Cryptococcus sp.
Marmara University