Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2024 , Vol 28 , Issue 4
Multicomponent crystals of fenofibric acid-L-proline with enhanced dissolution rate and antihyperlipidemic activity
Deni ANGGRAINI1,Erizal ZAINI2
1Sekolah Tinggi Ilmu Farmasi Riau , Pekanbaru, Indonesia
2Department of Pharmaceutic, Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia
DOI : 10.29228/jrp.780 The objectives of this study were to prepare and characterize a novel fenofibric acid-L prolin multicomponent crystals and to evaluate the improvement in dissolution rate and antihiperlipidemic activity of fenofibric acid when prepared in the multicomponent crystal formation. The solid-state characterization of the novel multicomponent crystal was performed by powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and Fourier transform-infrared (FT-IR) spectroscopy. The multicomponent crystals of fenofibric acid (FA) and L-prolin (PR) was prepared by solvent drop grinding method. Dissolution rate profiles were evaluated in phosphate buffer pH 6.8 . To investigate the in vivo antihiperlipidemic activity, 16 male Swiss-Webster rat were injected with cholesterol-inductor solution 1%, following oral administration of intact fenofibric acid 9,45 mg/kg, physical mixture, and multicomponent crystals fenofibric acid- L-proline (equivalent to 9,45 mg/ kg fenofibric acid). The plasma level of cholesterol was determine with photometer. All data were analyzed with two-way ANOVA followed by Tukey HSD test (95% confidence interval). The results of the antihyperlipidemia test showed that the cholesterol levels of animals treated with multicomponen crystals FA-PR lower than the cholesterol levels of animals treated with fenofibric acid and physical mixture (significance <0,05). The Solubility and dissolution rate of multicomponent crystals FA-PR were also improved significantly compared to intact fenofibric acid. Keywords : Fenofibric acid ; L-Proline ; Multicomponen crystals ; Solubility ; Dissolution rate
Marmara University