¹Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Palembang, Indonesia
²Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Palembang, Indonesia
³Department of Pharmacy, Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatera, Indonesia DOI : 10.12991/jrp.2024.00 The liver—the center of metabolism and detoxification—is especially susceptible to damage from toxins and must be protected. This study aimed to evaluate the hepatoprotective effects of the ethyl acetate fraction from three Indonesian Artocarpus species (Artocarpus altilis, A. champeden, and A. heterophyllus) in rats with acute liver injury induced by carbon tetrachloride (CCl4). The hepatoprotective effect was assessed through biochemical parameters (AST, ALT, and ALP) and histological analysis of the liver of the test group and compared to the normal control group (Na CMC 0.5%) and the positive control group (silymarin 100 mg/kg). There was no significant difference between the AST, ALT, and ALP levels in the 500 mg dose group, the control and the silymarin group (p > 0.05). Histological analysis of the liver tissue showed a microscopic profile similar to that of the control and silymarin groups. This study showed that the ethyl acetate fraction of Artocarpus altilis, A. heterophyllus, and A. champeden has synergistic potential as a hepatoprotector against liver injury caused by CCl₄. Consequently, the leaves of these species can be used as complementary medicine in treating acute liver damage. Keywords : Ethyl acetate fraction; Artocarpus altilis; Artocarpus heterophyllus; Artocarpus champeden; acute liver damage