Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2024 , Vol 28 , Issue 3
Clinical assessment of an ointment obtained from Alkanna orientalis root extract in the management of burn wounds: a pilot cross-sectional clinical trial
Farnoush SEYYEDI1,Kavous SHAHSAVARINIA2,Babak DAVAMI3,Hossein NAZEMIYEH1,Aliasghar KHEIRI3,Hadi VALIZADEH4,Laleh KHODAIE1,Afshin GHAREKHANI5
1Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of General Surgery, Sina Educational, Research and Treatment Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Clinical Pharmacy (Pharmacotherapy), Imam Reza Medical Research & Training Hospital, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
6Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran DOI : 10.29228/jrp.723 Alkanna orientalis is known as a wound healing herb in Persian medicine. This study aimed to evaluate the effect of the ointment prepared from the extract of A. orientalis roots on the treatment of grade 1 and 2 burn injuries. Methods: This study was performed over one year in Sina hospital of Tabriz University of Medical Sciences. Patients, based on inclusion criteria, were divided into two categories of control and intervention groups. The control group received the current protocol of burn care of Sina hospital, while the case group received the routine treatment protocol alongside the herbal formulation for burn injury. The parameters indicating the efficacy of the herbal ointment were studied in both groups. Results: this study was performed on 60 patients (30 males and 30 females). The results showed that the patients who received herbal ointment formulation experienced a shorter duration of treatment and better therapeutic response. Also, the application of herbal formulation prevented the progression of wounds to higher grades. The duration of epithelial layer formation at the wound bed in control and intervention groups was 6.5±0.2 and 3.4±0.3 days (P-value<0.05), respectively. Successively, the rate of complete recovery of wound in control and intervention groups was 46.7% and 73.3% (P-value<0.05). The herbal ointment accelerated the recovery by 3.1±0.1 days (P-value<0.05). Conclusion: the results of this pilot study illustrated the efficacy of the prepared formulation on burn injuries which could be used alongside the conventional treatment protocol of burn care. Keywords : Alkanna orientalis; burn; wound healing; ointment; herbal extract
Marmara University